|
KMID : 0613820030130060943
|
|
Journal of Life Science
2003 Volume.13 No. 6 p.943 ~ p.949
|
|
|
Syntheses and Antibacterial Activities of New Quinolones Containing cis- or trans-3-Amino-4-methylthiomethylpyrrolidine Moiety
|
|
Lee Jae-Wook
Lim Gui-Taek
|
|
|
Abstract
|
|
|
|
New quinolone derivatives of 7-(cis- or trans-3-amino-4-methylthiomethylpyrrolidinyl) quinolone-3-carboxylic acids were synthesized by condensation of 7-halo substituted quinolone-3-carboxylic acids with cis- or trans-3-amino-4- methylthiomethylpyrrolidine. Some of these compounds showed broad spectra of antibacterial activities against Gram-positive and Gram-negative organisms except Pseudomonas aeruginosa, and exhibited much stronger activity against MRSA.
|
|
|
KEYWORD
|
|
|
antibacterial agents, antibacterial activities, pyrrolidine, quinolone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|